SCID and Wild-Type Mice Nonhairpin Coding Ends in Thymocytes of Variable Diversity Joining Recombination:
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Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice.
Initiation of V(D)J recombination results in broken DNA molecules with blunt recombination signal ends and covalently sealed (hairpin) coding ends. In SCID mice, coding joint formation is severely impaired and hairpin coding ends accumulate as a result of a deficiency in the catalytic subunit of DNA-dependent protein kinase, an enzyme involved in the repair of DNA double-strand breaks. In this ...
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تاریخ انتشار 2002